Background: Cellular diversity of the lung endothelium has not been systematically
characterized in humans. We provide a reference atlas of human lung endothelial cells (ECs) to …

Rationale: Cystic fibrosis (CF) is a life-shortening, multisystem hereditary disease caused by
abnormal chloride transport. CF lung disease is driven by innate immune dysfunction and …

Rationale: MicroRNAs are potent regulators of biologic systems that are critical to tissue
homeostasis. Individual microRNAs have been identified in airway samples. However, a …

Sepsis is a leading cause of death worldwide and recent studies have shown white adipose
tissue (WAT) to be an important regulator in septic conditions. In the present study, the role …

Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, however
our understanding of cell specific mechanisms underlying COPD pathobiology remains …

Cellular senescence is a cell fate implicated in the pathogenesis of idiopathic pulmonary
fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). Cellular senescence occurs …

Excessive inflammation drives the progression from sepsis to septic shock. Macrophage
migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict …

Rationale: Cigarette smoke (CS) inhalation triggers oxidative stress and inflammation, leading
to accelerated lung aging, apoptosis, and emphysema, as well as systemic pathologies. …

90% of esophageal cancer are esophageal squamous cell carcinoma (ESCC) and ESCC
has a very poor prognosis and high mortality. Nevertheless, the key metabolic pathways …