H-Ras and N-Ras become activated both at the plasma membrane and in endomembrane
structures such as the Golgi apparatus. This compartmentalized activation is relevant from a …

Rho family GTPases are critical regulators of cellular functions that play important roles in
cancer progression. Aberrant activity of Rho small G-proteins, particularly Rac1 and their …

Here we describe a new signaling cross-talk between the Vav/Rac1 and Ras pathways that
is established through the stimulation of RasGRP1, an exchange factor for Ras subfamily …

We have used an extensive mutagenesis approach to study the specific role of the eight
structural domains of Vav during both the activation and signaling steps of this Rac1 exchange …

A relevant fraction of BRCA2 variants is associated with splicing alterations and with an
increased risk of hereditary breast and ovarian cancer (HBOC). In this work, we have carried out …

The members of the chimaerin family of Rac-GTPase-activating proteins possess a single
C1 domain with high homology to those present in protein kinase C (PKC) isozymes. This …

The regulation and function of β2-chimaerin, a novel receptor for the phorbol ester tumour
promoters and the second messenger DAG (diacylglycerol), is largely unknown. As with PKC (…

Gammaherpesviruses subvert eukaryotic signaling pathways to favor latent infections in their
cellular reservoirs. To this end, they express proteins that regulate or replace functionally …

Simple Summary Genetic variants in more than 10 genes are known to confer moderate to
high risks to breast and/or ovarian cancers (BC/OC). In the framework of the international …

β2-chimaerin, a member of the GTPase-activating proteins for the small GTP-binding protein
p21Rac, possesses a single cysteine-rich domain with high homology to those implicated in …