Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease …

M Manczak, TS Anekonda, E Henson… - Human molecular …, 2006 - academic.oup.com
Alzheimer's disease (AD) is a complex, neurodegenerative disease characterized by the
impairment of cognitive function in elderly individuals. In a recent global gene expression study …

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease …

M Manczak, MJ Calkins, PH Reddy - Human molecular genetics, 2011 - academic.oup.com
The purpose of our study was to better understand the relationship between mitochondrial
structural proteins, particularly dynamin-related protein 1 (Drp1) and amyloid beta (Aβ) in the …

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of …

MJ Calkins, M Manczak, P Mao… - Human molecular …, 2011 - academic.oup.com
Increasing evidence suggests that the accumulation of amyloid beta (Aβ) in synapses and
synaptic mitochondria causes synaptic mitochondrial failure and synaptic degeneration in …

Mitochondria-targeted antioxidants protect against amyloid-β toxicity in Alzheimer's disease neurons

M Manczak, P Mao, MJ Calkins… - Journal of …, 2010 - content.iospress.com
The purpose of our study was to investigate the effects of the mitochondria-targeted antioxidants,
MitoQ and SS31, and the anti-aging agent resveratrol on neurons from a mouse model (…

Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: implications for early mitochondrial dysfunction and oxidative damage

M Manczak, BS Park, Y Jung, PH Reddy - Neuromolecular medicine, 2004 - Springer
In Alzheimer’s disease (AD) pathogenesis, increasing evidence implicates mitochondrial
dysfunction resulting from molecular defects in oxidative phosphorylation (OXPHOS). The …

Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction

…, W Whetsell Jr, J Kaye, M Manczak - Journal of …, 2005 - content.iospress.com
The objective of our research was to determine synaptic protein levels in brain specimens
from AD subjects and age-matched control subjects. Further, to determine whether …

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial …

M Manczak, PH Reddy - Human molecular genetics, 2012 - academic.oup.com
We recently reported increased mitochondrial fission and decreased fusion, increased amyloid
beta (Aβ) interaction with the mitochondrial fission protein Drp1, increased mitochondrial …

[HTML][HTML] Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant …

…, MJ Calkins, AP Reddy, P Mao, M Manczak - … et Biophysica Acta (BBA …, 2012 - Elsevier
Synaptic pathology and mitochondrial oxidative damage are early events in Alzheimer's
disease (AD) progression. Loss of synapses and synaptic damage are the best correlates of …

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage

U Shirendeb, AP Reddy, M Manczak… - Human molecular …, 2011 - academic.oup.com
The purpose of our study was to determine the relationship between mutant huntingtin (Htt)
and mitochondrial dynamics in the progression of Huntington's disease (HD). We measured …

Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early …

…, S McWeeney, BS Park, M Manczak… - Human molecular …, 2004 - academic.oup.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
impairment of cognitive functions and by beta amyloid (Aβ) plaques in the cerebral cortex …