Our objective was to construct and validate a Multidimensional Prognostic Index (MPI) for 1-year
mortality from a Comprehensive Geriatric Assessment (CGA) routinely carried out in …

Background: Drug use increases with advancing age, and in older patients it is associated
with an increase in adverse drug reactions (ADRs). ADRs are a primary cause of morbidity …

Background & Aims: Several nonsteroidal anti-inflammatory drugs (NSAIDs) are metabolized
by the cytochrome P450 2C9 (CYP2C9). Two common variants of the CYP2C9 gene (…

Background— Multidimensional impairment of older patients may influence the clinical
outcome of diseases. The aim of this study was to evaluate whether a Multidimensional …

There are few diseases whose incidence varies as greatly worldwide as that of diverticulosis.
Its prevalence is largely age-dependent: the disease is uncommon in those under the age …

OBJECTIVES: To compare symptoms and other clinical characteristics of reflux esophagitis
in patients of different ages. DESIGN: Observational cross‐sectional study of consecutive …

Background and aims: Although the administration of gastroprotective drugs may reduce the
risk of gastrointestinal (GI) bleeding due to intake of non-steroidal anti-inflammatory drugs (…

Since the discovery of Helicobacter pylori (H. pylori) infection as the major cause of
gastroduodenal disorders three decades ago, H. pylori has been the focus of active research and …

The most frequent pancreatic cancer is pancreatic adenocarcinoma. It has high and early
locally and distant invasiveness; this is the reason why it often shows little sign or symptoms in …

Background The relationship between NSAID use and gastrointestinal (GI) symptoms and
their treatment in elderly patients is not well defined. Objectives To identify the prevalence of …