Adiponectin is an adipocyte-specific secretory protein that circulates in serum as a hexamer
of relatively low molecular weight (LMW) and a larger multimeric structure of high molecular …

OBJECTIVE: This article examines the foundation of β-cell failure in type 2 diabetes (T2D)
and suggests areas for future research on the underlying mechanisms that may lead to …

Leptin, the protein encoded by the obese (ob) gene, is synthesized and released in response
to increased energy storage in adipose tissue 1 , 2 , 3 , 4 . However, it is still not known …

Hyperglycemia is a major independent risk factor for diabetic macrovascular disease. The
consequences of exposure of endothelial cells to hyperglycemia are well established. …

Intraabdominal adiposity and insulin resistance are risk factors for diabetes mellitus,
dyslipidemia, arteriosclerosis, and mortality. Leptin, a fat-derived protein encoded by the ob gene, …

To examine whether the hexosamine biosynthetic pathway might play a role in fat-induced
insulin resistance, we monitored the effects of prolonged elevations in FFA availability both …

Long term administration of leptin decreases caloric intake and fat mass and improves
glucose tolerance. Here we examine whether leptin acutely regulates peripheral and hepatic …

Background. Resveratrol, a plant-derived polyphenol, has shown promising effects on
insulin sensitivity and glucose tolerance in animal models and is also reported to have …

Hyperinsulinemia and increased visceral/abdominal fat (VF) are common features of human
aging. To examine the relationships among VF, peripheral, and hepatic insulin sensitivity, …

Adipocytes release the secretory protein adiponectin in a number of different higher-order
complexes. Once synthesized and assembled in the secretory pathway of the adipocyte, these …