Context Adipose tissue is increasingly recognized as an active endocrine organ with many
secretory products and part of the innate immune system. With obesity, macrophages infiltrate …

Background Observational studies support an association between a low blood 25-hydroxyvitamin
D level and the risk of type 2 diabetes. However, whether vitamin D supplementation …

Objectives: We tested whether African-American (AA) women are different from Caucasian
women in regard to lipotoxicity, adipokines, and gene expression in adipose tissue and …

Adipose tissue macrophages are associated with insulin resistance and are linked to changes
in the extracellular matrix. To better characterize adipose macrophages, the extracellular …

To examine the role of adipose-resident macrophages in insulin resistance, we examined the
gene expression of CD68, a macrophage marker, along with macrophage chemoattractant …

Lipid droplet proteins of the PAT (perilipin, adipophilin, and TIP47) family regulate cellular
neutral lipid stores. We have studied a new member of this family, PAT-1, and found that it is …

Context: Insulin resistance is associated with inflammation, fibrosis, and hypoxia in adipose
tissue. Objective: This study was intended to better characterize the extracellular matrix (ECM…

Context: Visfatin (VF) is a recently described adipokine preferentially secreted by visceral
adipose tissue (VAT) with insulin mimetic properties. Objective: The aim of this study was to …

Heart failure (HF) has been recognized as a common complication of diabetes, with a
prevalence of up to 22% in individuals with diabetes and increasing incidence rates. Data also …

Background Dapagliflozin is a sodium-glucose cotransporter-2 inhibitor approved for the
treatment of type 2 diabetes. We aimed to assess the efficacy and safety of dapagliflozin as an …