User profiles for Oren Shaked

Oren Shaked

Verified email at pennmedicine.upenn.edu
Cited by 453

CRISPR screen in regulatory T cells reveals modulators of Foxp3

…, E Shifrut, J Gatchalian, Y Zhang, O Shaked… - Nature, 2020 - nature.com
Regulatory T (T reg ) cells are required to control immune responses and maintain
homeostasis, but are a significant barrier to antitumour immunity 1 . Conversely, T reg instability, …

Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks

JW Freimer, O Shaked, S Naqvi, N Sinnott-Armstrong… - Nature …, 2022 - nature.com
Gene regulatory networks ensure that important genes are expressed at precise levels. When
gene expression is sufficiently perturbed, it can lead to disease. To understand how gene …

Acute-on-chronic liver failure before liver transplantation: impact on posttransplant outcomes

R Bahirwani, O Shaked, M Bewtra, K Forde… - …, 2011 - journals.lww.com
Background. Acute decompensation in patients with chronic liver disease, resulting from
acute kidney injury and infections, leads to significant morbidity and mortality. It is unclear …

Novel benchmark for adult-to-adult living-donor liver transplantation: integrating Eastern and Western experiences

…, SC Hsu, EO Kirimker, N Akamatsu, O Shaked… - Annals of …, 2023 - journals.lww.com
Objective: To define benchmark values for adult-to-adult living-donor liver transplantation (LDLT).
Background: LDLT utilizes living-donor hemiliver grafts to expand the donor pool and …

Biologic and clinical features of benign solid and cystic lesions of the liver

O Shaked, ES Siegelman, K Olthoff… - Clinical Gastroenterology …, 2011 - Elsevier
The widespread use of imaging analyses, either routinely or to evaluate symptomatic
patients, has increased the detection of liver lesions (tumors and cysts) in otherwise healthy …

Design and implementation of the international genetics and translational research in transplantation network

…, C Hou, T Lee, L Steel, O Shaked… - …, 2015 - d-scholarship.pitt.edu
Background. Genetic association studies of transplantation outcomes have been hampered
by small samples and highly complex multifactorial phenotypes, hindering investigations of …

Hydrometrocolpos—diagnostic and therapeutic dilemmas

O Shaked, R Tepper, Z Klein, Y Beyth - Journal of pediatric and adolescent …, 2008 - Elsevier
Congenital distal vaginal obstruction is a rare condition, usually asymptomatic until
menarche, thus often diagnosed only during puberty. Hydrometrocolpos is caused by such an …

Complex wound management in ventricular assist device (VAD) patients: the role of aggressive debridement and vascularized soft tissue coverage

JA Nelson, O Shaked, JP Fischer… - Annals of plastic …, 2014 - journals.lww.com
Background Infections and complex wounds after ventricular assist device (VAD) placement
can result in significant morbidity and mortality. The purpose of this study was to evaluate …

Biliary complications after adult-to-adult living-donor liver transplantation: An international multicenter study of 3633 cases

…, SC Hsu, EO Kirimker, N Akamatsu, O Shaked… - American Journal of …, 2024 - Elsevier
In living-donor liver transplantation, biliary complications including bile leaks and biliary
anastomotic strictures remain significant challenges, with incidences varying across different …

Impact of donor and recipient clinical characteristics and hepatic histology on steatosis/fibrosis following liver transplantation

O Shaked, J Demetris, J Levitsky, S Feng… - …, 2022 - journals.lww.com
Background. Deceased donor and recipient predictors of posttransplant steatosis/steatohepatitis
and fibrosis are not well known. Our aim was to evaluate the prevalence and assess …