User profiles for Oren Shaked
Oren ShakedVerified email at pennmedicine.upenn.edu Cited by 453 |
CRISPR screen in regulatory T cells reveals modulators of Foxp3
Regulatory T (T reg ) cells are required to control immune responses and maintain
homeostasis, but are a significant barrier to antitumour immunity 1 . Conversely, T reg instability, …
homeostasis, but are a significant barrier to antitumour immunity 1 . Conversely, T reg instability, …
Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks
Gene regulatory networks ensure that important genes are expressed at precise levels. When
gene expression is sufficiently perturbed, it can lead to disease. To understand how gene …
gene expression is sufficiently perturbed, it can lead to disease. To understand how gene …
Acute-on-chronic liver failure before liver transplantation: impact on posttransplant outcomes
Background. Acute decompensation in patients with chronic liver disease, resulting from
acute kidney injury and infections, leads to significant morbidity and mortality. It is unclear …
acute kidney injury and infections, leads to significant morbidity and mortality. It is unclear …
Novel benchmark for adult-to-adult living-donor liver transplantation: integrating Eastern and Western experiences
…, SC Hsu, EO Kirimker, N Akamatsu, O Shaked… - Annals of …, 2023 - journals.lww.com
Objective: To define benchmark values for adult-to-adult living-donor liver transplantation (LDLT).
Background: LDLT utilizes living-donor hemiliver grafts to expand the donor pool and …
Background: LDLT utilizes living-donor hemiliver grafts to expand the donor pool and …
Biologic and clinical features of benign solid and cystic lesions of the liver
The widespread use of imaging analyses, either routinely or to evaluate symptomatic
patients, has increased the detection of liver lesions (tumors and cysts) in otherwise healthy …
patients, has increased the detection of liver lesions (tumors and cysts) in otherwise healthy …
Design and implementation of the international genetics and translational research in transplantation network
…, C Hou, T Lee, L Steel, O Shaked… - …, 2015 - d-scholarship.pitt.edu
Background. Genetic association studies of transplantation outcomes have been hampered
by small samples and highly complex multifactorial phenotypes, hindering investigations of …
by small samples and highly complex multifactorial phenotypes, hindering investigations of …
Hydrometrocolpos—diagnostic and therapeutic dilemmas
O Shaked, R Tepper, Z Klein, Y Beyth - Journal of pediatric and adolescent …, 2008 - Elsevier
Congenital distal vaginal obstruction is a rare condition, usually asymptomatic until
menarche, thus often diagnosed only during puberty. Hydrometrocolpos is caused by such an …
menarche, thus often diagnosed only during puberty. Hydrometrocolpos is caused by such an …
Complex wound management in ventricular assist device (VAD) patients: the role of aggressive debridement and vascularized soft tissue coverage
Background Infections and complex wounds after ventricular assist device (VAD) placement
can result in significant morbidity and mortality. The purpose of this study was to evaluate …
can result in significant morbidity and mortality. The purpose of this study was to evaluate …
Biliary complications after adult-to-adult living-donor liver transplantation: An international multicenter study of 3633 cases
…, SC Hsu, EO Kirimker, N Akamatsu, O Shaked… - American Journal of …, 2024 - Elsevier
In living-donor liver transplantation, biliary complications including bile leaks and biliary
anastomotic strictures remain significant challenges, with incidences varying across different …
anastomotic strictures remain significant challenges, with incidences varying across different …
Impact of donor and recipient clinical characteristics and hepatic histology on steatosis/fibrosis following liver transplantation
O Shaked, J Demetris, J Levitsky, S Feng… - …, 2022 - journals.lww.com
Background. Deceased donor and recipient predictors of posttransplant steatosis/steatohepatitis
and fibrosis are not well known. Our aim was to evaluate the prevalence and assess …
and fibrosis are not well known. Our aim was to evaluate the prevalence and assess …