Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due
to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of …

The aging suppressor gene Klotho encodes a single-pass transmembrane protein. Klotho-deficient
mice exhibit a variety of aging-like phenotypes, many of which are similar to those …

The formation of stones in the urinary tract stems from a wide range of underlying disorders.
That clinicians look for the underlying causes for nephrolithiasis is imperative to direct …

Soft-tissue calcification is a prominent feature in both chronic kidney disease (CKD) and
experimental Klotho deficiency, but whether Klotho deficiency is responsible for the calcification …

The metabolic syndrome and uric acid nephrolithiasis: Novel features of renal manifestation
of insulin resistance. Background Uric acid nephrolithiasis primarily results from low urinary …

Klotho has profound effects on phosphate metabolism, but the mechanisms of how Klotho
affects phosphate homeostasis is unknown. We detected Klotho in the proximal tubule cell, …

The metabolically active and perpetually remodeling calcium phosphate–based endoskeleton
in terrestrial vertebrates sets the demands on whole-organism calcium and phosphate …

Autophagy increases the lifespan of model organisms; however, its role in promoting
mammalian longevity is less well-established 1 , 2 . Here we report lifespan and healthspan …

Klotho is an antiaging substance with pleiotropic actions including regulation of mineral
metabolism. It is highly expressed in the kidney and is present in the circulation and urine but its …

Urate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome,
but its relationship to kidney disease, cardiovascular disease, and diabetes remains …