The von Hippel–Lindau tumor suppressor gene product, pVHL, functions as the substrate
recognition component of an E3-ubiquitin ligase, which targets the oxygen-sensitive α-subunit …

… PP Kapitsinou and VH Haase contributed equally to this work. Address for reprint requests
and other correspondence: PP Kapitsinou… * PP Kapitsinou and VH Haase contributed equally …

The kidney is the main physiologic source of erythropoietin (EPO) in the adult and responds
to decreases in tissue oxygenation with increased EPO production. Although studies in mice …

The hypoxia-inducible transcription factors HIF-1 and HIF-2 mediate key cellular adaptions to
hypoxia and contribute to renal homeostasis and pathophysiology; however, little is known …

Hypoxia-inducible factors 1 and 2 (HIF-1 and -2) control oxygen supply to tissues by regulating
erythropoiesis, angiogenesis and vascular homeostasis. HIFs are regulated in response …

… may be due to the short duration of HIF activation, but it may also indicate that HIF has cell
type-specific functions with regard to fibrosis development (Kobayashi and Haase; Kapitsinou …

Renal fibrosis and inflammation are associated with hypoxia, and tissue pO 2 plays a central
role in modulating the progression of chronic kidney disease. Key mediators of cellular …

Renal peritubular interstitial fibroblast-like cells are critical for adult erythropoiesis, as they
are the main source of erythropoietin (EPO). Hypoxia-inducible factor 2 (HIF-2) controls EPO …

Prolonged cellular hypoxia leads to energetic failure and death. However, sublethal hypoxia
can trigger an adaptive response called hypoxic preconditioning. While prolyl-hydroxylase (…

Objective. To evaluate the safety and efficacy of mycophenolate mofetil (MMF) treatment in
patients with lupus nephritis. Methods. Eighteen patients with biopsy-proven lupus nephritis (…