Cutaneous melanoma is a type of cancer with an inherent potential for lymph node colonization,
which is generally preceded by neolymphangiogenesis 1 , 2 , 3 . However, sentinel …

An open question in aggressive cancers such as melanoma is how malignant cells can shift
the immune system to pro-tumorigenic functions. Here we identify midkine (MDK) as a …

Background: Matrix metalloproteinases (MMP) are important enzymes in the tumor
microenvironment associated with progression of cervical intraepithelial neoplasia (CIN) toward …

A bioassay-guided study aiming at identifying inhibitors of the glycation process on the leaves
of Ocotea paranapiacabensis afforded four benzylisoquinoline alkaloids (1–4), with 1 and …

In melanoma development, oncogenic process is mediated by genetic and epigenetic
mutations, and few studies have so far explored the role of DNA methylation either as …

Epigenetic dysregulation is an important emerging hallmark of cutaneous melanoma
development. The global loss of DNA methylation in gene-poor regions and transposable DNA …

Background Cutaneous melanoma (CM) is the most aggressive subtype of skin cancer, with
increasing incidence over the past several decades. DNA methylation is a key element of …

The impact of advanced glycation end products (AGEs) accumulation is associated with the
development and exacerbation of many degenerative processes and disorders, including …

In melanoma development, oncogenic process is mediated by genetic and epigenetic
mutations, and few studies have so far explored the role of DNA methylation either as …

The advanced glycation end products (AGEs) of proteins are common factors in the
pathophysiology of a number of disorders related to aging. The skin generation of AGEs occurs …