Monozygotic or ‘identical’ twins have been widely studied to dissect the relative contributions
of genetics and environment in human diseases. In multiple sclerosis (MS), an autoimmune …

Genome-wide association studies (GWAS) testing several hundred thousand SNPs have
been performed in multiple sclerosis (MS) and other complex diseases. Typically, the number …

10.7554/eLife.26726.001 The ability to computationally predict whether a compound treats
a disease would improve the economy and success rate of drug approval. This study …

The 1000 Genomes Project aims to provide a deep characterization of human genome
sequence variation by sequencing at a level that should allow the genome-wide detection of …

Multiple sclerosis (MS) is an inflammatory CNS disease with a substantial genetic component,
originally mapped to only the human leukocyte antigen (HLA) region. In the last 5 years, a …

Glutamate is the main excitatory neurotransmitter in the mammalian brain. Appropriate
transmission of nerve impulses through glutamatergic synapses is required throughout the brain …

Objective To understand the nature of genetic and environmental susceptibility to multiple
sclerosis (MS) and, by extension, susceptibility to other complex genetic diseases. …

Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous
system (CNS). It is characterized by the infiltration of autoreactive immune cells into the CNS, …

The aims of this study were: (i) to determine to what degree multiple sclerosis-associated
loci discovered in European populations also influence susceptibility in African Americans; (ii) …

Objectives: To assess the association of established multiple sclerosis (MS) risk variants in
3,254 African Americans (1,162 cases and 2,092 controls). Methods: Human leukocyte …