Successful repair after tissue injury and inflammation requires resolution of the inflammatory
response and removal of extracellular matrix breakdown products. We have examined …

Removal of cells dying by apoptosis is essential to normal development, maintenance of
tissue homeostasis, and resolution of inflammation. Surfactant protein A (SP-A) and surfactant …

Cystic fibrosis is characterized by an early and sustained influx of inflammatory cells into the
airways and by release of proteases. Resolution of inflammation is normally associated with …

Apoptosis and the removal of apoptotic cells (termed efferocytosis) are tightly coupled with
the regulation of normal lung structure, both in the developing and adult organism. Processes …

Vascular endothelial growth factor (VEGF) is a pluripotent growth and permeability factor that
has a broad impact on endothelial cell function. The lung tissue is very rich in this protein; …

PPARγ is a member of a family of nuclear receptors/ligand–dependent transcription factors,
which bind to hormone response elements on target gene promoters. An antiproliferative …

… Lovastatin also suppresses matrix metalloproteinase-9 (8), which inhibits efferocytosis in
vitro (RW Vandivier, unpublished data), and is an important component of lung inflammation. …

… Importantly, when Vandivier and colleagues added target cells to macrophages that had
been incubated on SP-A– or SP-D–coated plates, phagocytosis was significantly reduced (20), …

Self-management strategies improve a variety of health-related outcomes for patients with
chronic obstructive pulmonary disease (COPD). These strategies, however, are primarily …

The mammalian ATP-binding cassette transporters A1 and A7 (ABCA1 and -A7) show
sequence similarity to CED-7, a Caenorhabditis elegans gene that mediates the clearance of …