The folate receptor is a highly selective tumor marker overexpressed in greater than 90% of
ovarian carcinomas. Two general strategies have been developed for the targeted delivery …

Folic acid was covalently conjugated to 66-nm liposomes via spacers of various lengths in
an attempt to target the liposomes to KB cells expressing folate receptors. Spacers of short …

Receptors for the vitamin folic acid are frequently overexpressed on epithelial cancer cells.
To examine whether this overexpression might be exploited to specifically deliver liposome-…

Reports of clinical trials often contain a wealth of data comparing treatments. This can lead
to problems in interpretation, particularly when significance testing is used extensively. We …

Objective To report the baseline prevalence of refractive error in the study population. Design
A multicenter, longitudinal, observational study of refractive error and ocular development …

Polyethylenimine (PEI) is a polycation with potential application as a nonviral vector for
gene delivery. Here we show that after conjugation with homobifunctional amine reactive …

Innate and adaptive defense mechanisms protect the respiratory system from attack by
microbes. Here, we present evidence that the bitter taste receptor T2R38 regulates the mucosal …

We have developed a lipidic gene transfer vector, LPDII, where DNA was first complexed to
polylysine at a ratio of 1:0.75 (w/w) and then entrapped into folate-targeted pH-sensitive …

Although hydrophilic small molecule drugs are widely used in the clinic, their rapid
clearance, suboptimal biodistribution, low intracellular absorption and toxicity can limit their …

Cell-penetrating peptides (CPPs) are short peptides (fewer than 30 amino acids) that have
been predominantly used in basic and preclinical research during the last 30 years. Since …