Identification of a major co-receptor for primary isolates of HIV-1
HK Deng, R Liu, W Ellmeier, S Choe, D Unutmaz… - Nature, 1996 - nature.com
Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A
cofactor required for infection with virus adapted for growth in transformed T-cell lines was …
cofactor required for infection with virus adapted for growth in transformed T-cell lines was …
[HTML][HTML] Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
R Liu, WA Paxton, S Choe, D Ceradini, SR Martin… - Cell, 1996 - cell.com
Rare individuals have been multiply exposed to HIV-1 but remain uninfected. The CD4 + T-cells
of two of these individuals, designated EU2 and EU3, are highly resistant in vitro to the …
of two of these individuals, designated EU2 and EU3, are highly resistant in vitro to the …
Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure
BACKGROUND: Despite widely reported clinical and preclinical studies of rapid antidepressant
actions of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists, there has been …
actions of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists, there has been …
A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
J Wang, R Liu, M Hawkins, N Barzilai, L Rossetti - Nature, 1998 - nature.com
Leptin, the protein encoded by the obese (ob) gene, is synthesized and released in response
to increased energy storage in adipose tissue 1 , 2 , 3 , 4 . However, it is still not known …
to increased energy storage in adipose tissue 1 , 2 , 3 , 4 . However, it is still not known …
mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists
The rapid antidepressant response after ketamine administration in treatment-resistant
depressed patients suggests a possible new approach for treating mood disorders compared to …
depressed patients suggests a possible new approach for treating mood disorders compared to …
Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
Programmed cell death (apoptosis) seems to be the principal mechanism whereby anti-oncogenic
therapies such as chemotherapy and radiation effect their responses. Resistance to …
therapies such as chemotherapy and radiation effect their responses. Resistance to …
[HTML][HTML] Guidelines for the diagnosis and treatment of hepatocellular carcinoma (2019 edition)
…, W Zhou, P Bie, L Liu, T Wen, G Han, M Wang, R Liu… - Liver cancer, 2020 - karger.com
Background: Primary liver cancer, around 90% are hepatocellular carcinoma in China, is
the fourth most common malignancy and the second leading cause of tumor-related death, …
the fourth most common malignancy and the second leading cause of tumor-related death, …
ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes
Autophagy, an important catabolic pathway implicated in a broad spectrum of human diseases,
begins by forming double membrane autophagosomes that engulf cytosolic cargo and …
begins by forming double membrane autophagosomes that engulf cytosolic cargo and …
Robust anomaly detection for multivariate time series through stochastic recurrent neural network
Industry devices (ie, entities) such as server machines, spacecrafts, engines, etc., are typically
monitored with multivariate time series, whose anomaly detection is critical for an entity's …
monitored with multivariate time series, whose anomaly detection is critical for an entity's …
[HTML][HTML] Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy
Autophagy is a stress response protecting cells from unfavorable conditions, such as nutrient
starvation. The class III phosphatidylinositol-3 kinase, Vps34, forms multiple complexes …
starvation. The class III phosphatidylinositol-3 kinase, Vps34, forms multiple complexes …