Sequences of 234 complete genomes and 631 hepatitis B surface antigen genes were used
to assess the worldwide diversity of hepatitis B virus (HBV). Apart from the described two …

Because of the shared modes of transmission, hepatitis B virus (HBV)/hepatitis C virus (HCV)
coinfection is not uncommon in highly endemic areas and among subjects with a high risk …

In contrast to many traditional pharmaceutical agents that exhibit a high degree of aqueous
solubility, new drug candidates are frequently highly lipophilic compounds. The aqueous …

Background Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin-12 and
interleukin-23, was evaluated as an intravenous induction therapy in two populations with …

Successful integration of advanced semiconductor devices with biological systems will
accelerate basic scientific discoveries and their translation into clinical technologies. In …

INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

We detected des-γ-carboxy prothrombin, an abnormal prothrombin, in the serum of 69 of 76
patients (91 per cent) with biopsy-confirmed hepatocellular carcinoma (the mean level of the …

Current therapies for chronic hepatitis B (CHB) have a number of limitations, and better
treatment options are needed. Peginterferon α‐2a (40 kDa) is superior to conventional interferon …

A more general incremental updating technique is developed for maintaining the association
rules discovered in a database in the cases including insertion, deletion, and modification …

Antituberculosis drug–induced hepatitis is one of the most prevalent drug-induced liver
injuries. Isoniazid is the major drug incriminated in this hepatotoxicity. Isoniazid is mainly …