The earliest recognizable atherosclerotic lesions are fatty streaks composed of lipid-laden
macrophages (foam cells). Circulating monocytes are the precursors of these foam cells, but …

Mutations in the nuclear envelope proteins lamins A and C cause a broad variety of human
diseases, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and …

Previous studies have established that low density lipoprotein (LDL) incubated with endothelial
cells (EC) undergoes extensive oxidative modification in structure and that the modified …

Zmpste24 is an integral membrane metalloproteinase of the endoplasmic reticulum. Biochemical
studies of tissues from Zmpste24-deficient mice (Zmpste24 −/− ) have indicated a role …

The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LpL) along the
luminal surface of the capillaries. However, the endothelial cell molecule that facilitates …

Defects in the endosomal-lysosomal pathway have been implicated in a number of
neurodegenerative disorders [1]. A key step in the endocytic regulation of transmembrane proteins …

A deficiency in microsomal triglyceride transfer protein (MTP) causes the human lipoprotein
deficiency syndrome abetalipoproteinemia. However, the role of MTP in the assembly and …

Lamins are key structural components of the nuclear lamina, an intermediate filament meshwork
that lies beneath the inner nuclear membrane. Lamins play a role in nuclear architecture…

The lipolytic processing of triglyceride-rich lipoproteins by lipoprotein lipase (LPL) is the
central event in plasma lipid metabolism, providing lipids for storage in adipose tissue and fuel …

Apolipoprotein (apo) E and the two B apolipoproteins, apoB48 and apoB100, are important
proteins in human lipoprotein metabolism. Commonly occurring polymorphisms in the genes …