We conducted a descriptive case study to examine the effects of sodium-glucose cotransporter
2 (SGLT2) inhibitors on urinary angiotensinogen excretion, which represents the function …

Background Recently, immune checkpoint inhibitors have widely been used for the
management of advanced melanoma. However, high-grade immune-related adverse events can …

Objective The chronic kidney disease (CKD) is widely diagnosed on the basis of albuminuria
and the glomerular filtration rate. A more precise diagnosis of CKD, however, requires the …

In pancreatic β cells, ABCA1, a 254 kDa membrane protein, affects cholesterol homeostasis
and insulin secretion. Angiotensin II, as the main effector of the renin–angiotensin system, …

Recently, several clinical studies have suggested that adult growth hormone (GH) deficiency
that also has low concentration of IGF1 is associated with an increased prevalence of fatty …

Thyroid stimulating hormone (TSH) stimulates the secretion of thyroid hormones by binding
the TSH receptor (TSHR). TSHR is well-known to be expressed in thyroid tissue, excepting it, …

ATP-binding cassette transporter A1 (ABCA1), a 254-kD membrane protein, is a key regulator
of lipid efflux from cells to apolipoproteins. ABCA1 in pancreatic β-cells influences insulin …

ATP-binding cassette transporter A1 (ABCA1) protein is a pivotal regulator of cholesterol
and phospholipid efflux from cells to high-density lipoprotein (HDL) particles. Pancreatic …

Infection by hepatitis C virus (HCV), a plus-stranded RNA virus that can cause cirrhosis and
hepatocellular carcinoma, is one of the major health problems in the world. HCV infection is …

A 17-year-old Japanese man was referred to our hospital because of highly elevated serum
levels of creatine kinase (CK) and transaminases. On admission, the proximal muscles of …