Histological activity reflects the global assessment of basic necroinflammatory lesions and
is a criterion of major importance in chronic hepatitis C. The aim of this study was to propose …

Background Our aim was to assess the natural history of liver fibrosis progression in hepatitis
C and the factors associated with this progression. Methods We recruited 2235 patients …

Background Only 15–20% of patients with chronic hepatitis C achieve a sustained virological
response with interferon therapy. The aim of this study was to compare the efficacy and …

Background & Aims: In nonalcoholic fatty liver disease (NAFLD), the distinction between
steatosis and steatohepatitis (NASH) and the assessment of the severity of the disease rely on …

Background Liver biopsy is thought mandatory for management of patients with hepatitis C
virus (HCV) infection, especially for staging fibrosis. We aimed, in our prospective study, to …

The natural history of hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)‐infected
patients has never been studied according to the concept of liver fibrosis …

BACKGROUND & AIMS: Liver fibrosis is an important prognostic factor in patients with
hepatitis C. The effect of pegylated (PEG) interferon alone or its combination with ribavirin on …

Epidemiology Chronic hepatitis C virus infection is a major cause of chronic liver disease
and death throughout the world. 1, 2, 4–9 Very effective treatment is now available, which …

Background & Aims: A common clinical issue is whether overweight patients with abnormal
liver function test results should undergo liver biopsy. Although serious liver injury can occur, …

Background & Aims: Patient adherence to prescribed antiviral therapy in human
immunodeficiency virus infection enhances response. We evaluated the impact of adherence to …