Ligands of the prototypical activating NK receptor NKG2D render cancer cells susceptible to
NK cell-mediated cytolysis if expressed at sufficiently high levels. However, malignant cells …

Epigenetic alterations are a hallmark of cancer that govern the silencing of genes. Up to now,
5-azacytidine (5-aza-CR, Vidaza) and 5-aza-2′-deoxycytidine (5-aza-dC, Dacogen) are …

Bone destruction is a prominent feature of multiple myeloma, but conflicting data exist on the
expression and pathophysiologic involvement of the bone remodeling ligand RANKL in this …

The TNF receptor family member OX40 promotes activation and proliferation of T cells, which
fuels efforts to modulate this immune checkpoint to reinforce antitumor immunity. Besides T …

The TNF family member receptor activator for NF-κB ligand (RANKL) and its receptors
RANK and osteoprotegerin are key regulators of bone remodeling but also influence cellular …

Natural killer (NK) cells are cytotoxic lymphocytes that largely contribute to the efficacy of
therapeutic strategies like allogenic stem cell transplantation in acute myeloid leukemia (AML) …

OX40 and its ligand are members of the TNF/TNF receptor superfamily, which includes
various molecules influencing cellular signaling and function of both tumor and immune cells. …

Background Co‐stimulatory receptor ( COR ) and ligand ( COL ) expression on immune
effectors are known to be relevant for immunological interactions and might be of prognostic …

Background: Tumor necrosis factor (TNF) receptor family members play a key role in the
regulation of biological functions such as differentiation, proliferation and apoptosis of various …

Costimulatory ligands (COLs) and their receptors (COR) regulate immune reactions and
cellular survival and might be relevant in acute myeloid leukemia (AML). This study evaluated …