A classic physiologic response to systemic hypoxia is the increase in red blood cell production.
Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type specific …

Tissue hypoxia not only occurs under pathological conditions but is also an important
microenvironmental factor that is critical for normal embryonic development. Hypoxia-inducible …

The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the
hypoxic induction of red blood cell production. Efforts to understand the molecular basis of …

Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular
agents of innate immunity. Here, we have examined the inflammatory response in mice with …

Neurofibromatosis 2 (NF2) is a dominantly inherited disorder characterized by the occurrence
of bilateral vestibular schwannomas and other central nervous system tumors including …

Hypoxia has been proposed as an important microenvironmental factor in the development
of tissue fibrosis; however, the underlying mechanisms are not well defined. To examine the …

Skeletal development and turnover occur in close spatial and temporal association with
angiogenesis. Osteoblasts are ideally situated in bone to sense oxygen tension and respond to …

Erythropoietin (Epo) controls red cell production in the basal state and during stress. Epo
binding to its receptor, EpoR, on erythroid progenitors leads to rapid activation of the …

Iron is essential for many biological processes, including oxygen delivery, and its supply is
tightly regulated. Hepcidin, a small peptide synthesized in the liver, is a key regulator of iron …

Mucosal epithelial cells are uniquely equipped to maintain barrier function even under
adverse conditions. Previous studies have implicated hypoxia in mucosal tissue damage …