In the last 20 years, we have observed an exponential growth of the DNA sequence data
and simular increase in the volume of DNA polymorphism data generated by numerous …

Despite a substantial investment in the development of panels of single nucleotide
polymorphism (SNP) markers, the simple sequence repeat (SSR) technology with a limited …

5-Fluorouracil (5FU) and oxaliplatin are standard therapy for metastatic colorectal cancer (CRC),
but the development of chemoresistance is inevitable. Because cancer stem cells (CSC…

We report a paracrine effect whereby endothelial cells (ECs) promote the cancer stem cell (CSC)
phenotype of human colorectal cancer (CRC) cells. We showed that, without direct cell-…

Endoglin (CD105) is an accessory protein of the transforming growth factor-β receptor system
expressed on vascular endothelial cells. Mutation of the endoglin gene is associated with …

Background Molecular marker technologies are undergoing a transition from largely serial
assays measuring DNA fragment sizes to hybridization-based technologies with high …

This article surveys the use of eye tracking in investigations of online search. Three eye
tracking experiments that we undertook are discussed and compared to additional work in this …

Altered metabolism in cancer cells is suspected to contribute to chemoresistance, but the
precise mechanisms are unclear. Here, we show that intracellular ATP levels are a core …

Epithelial–mesenchymal transition ( EMT ) is a critical process providing tumor cells with the
ability to migrate and escape from the primary tumor and metastasize to distant sites. …

The selenoprotein thioredoxin reductase (TrxR1) is an essential antioxidant enzyme known
to reduce many compounds in addition to thioredoxin, its principle protein substrate. Here …