Targeted delivery of therapeutic nanoparticles in a disease-specific manner represents a
potentially powerful technology especially when treating infiltrative brain tumors such as …

The dissemination, seeding, and colonization of circulating tumor cells (CTCs) serve as the
root of distant metastasis. As a key step in the early stage of metastasis formation, …

The lactoferrin (Lf) conjugated poly (ethyleneglycol)–poly (lactide) nanoparticle (Lf–NP) was
constructed in this paper as a novel biodegradable brain drug delivery system with …

Nanoparticulate drug delivery system possesses distinct advantages for brain drug delivery.
However, its amount that reach the brain is still not satisfied. Cell-penetrating peptides (…

By taking advantage of the dramatically upregulated expression of matrix metalloproteinases
MMP-2 and MMP-9 in glioblastomas and the powerful transport ability of low molecular …

In order to improve the absorption of nanoparticles in the brain following nasal administration,
a novel protocol to conjugate biorecognitive ligands—lectins to the surface of poly (…

A novel drug carrier for brain delivery, poly(ethyleneglycol)-poly(ε-caprolactone) (PEG-PCL)
polymersomes conjugated with mouse-anti-rat monoclonal antibody OX26 (OX26-PO), was …

The development of biotech drugs such as peptides and proteins that act in the central
nervous system has been significantly impeded by the difficulty of delivering them across the …

The development of a drug delivery strategy which can mediate efficient tumor targeting
together with high cellular internalization and extensive vascular extravasation is essential and …

Amyloid-beta (Aβ) accumulation in the brain is believed to play a central role in Alzheimer’s
disease (AD) pathogenesis, and the common late-onset form of AD is characterized by an …