Ixekizumab, an interleukin-17A antagonist in the treatment of ankylosing spondylitis or radiographic axial spondyloarthritis in patients previously untreated with …
…, MC Park, K Shin, SH Lee, HA Chen, YC Chen… - The Lancet, 2018 - thelancet.com
Background Biological disease-modifying anti-rheumatic drugs (bDMARDs) are recommended
for radiographic axial spondyloarthritis, otherwise known as ankylosing spondylitis, when …
for radiographic axial spondyloarthritis, otherwise known as ankylosing spondylitis, when …
[HTML][HTML] Baricitinib in patients with inadequate response or intolerance to conventional synthetic DMARDs: results from the RA-BUILD study
M Dougados, D van der Heijde, YC Chen… - Annals of the …, 2017 - ard.bmj.com
Background Baricitinib is an oral, reversible, selective Janus kinase 1 and 2 inhibitor.
Methods In this phase III, double-blind 24-week study, 684 biologic disease-modifying …
Methods In this phase III, double-blind 24-week study, 684 biologic disease-modifying …
Three multicenter, randomized, double‐blind, placebo‐controlled studies evaluating the efficacy and safety of ustekinumab in axial spondyloarthritis
…, DY Chen, HC Chen, KH Chen, YC Chen… - Arthritis & …, 2019 - Wiley Online Library
Objective To evaluate the efficacy and safety of ustekinumab in 3 randomized, placebo‐controlled
studies in patients with axial spondyloarthritis (SpA). Studies 1 and 2 included patients …
studies in patients with axial spondyloarthritis (SpA). Studies 1 and 2 included patients …
[HTML][HTML] Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy
…, HJ Tsai, KH Hu, HC Chang, CW Yeh, YC Chen… - Scientific reports, 2012 - nature.com
To investigate whether altered energy metabolism induces the Warburg effect and results in
tumor malignancy, the respiratory enzyme citrate synthase (CS) was examined, silenced …
tumor malignancy, the respiratory enzyme citrate synthase (CS) was examined, silenced …
Cumulative immunosuppressant exposure is associated with diversified cancer risk among 14 832 patients with systemic lupus erythematosus: a nested case–control …
Objectives. Immunosuppressive therapy is necessary to alter the natural course of SLE.
However, immunosuppressant-related cancer risk is a major concern. The aim of this study was …
However, immunosuppressant-related cancer risk is a major concern. The aim of this study was …
Gout and type 2 diabetes have a mutual inter-dependent effect on genetic risk factors and higher incidences
HM Lai, CJ Chen, BYJ Su, YC Chen, SF Yu… - …, 2012 - academic.oup.com
Objective. To explore the causal relationship between gout and Type 2 diabetes based on
genetic evidence and national outpatient database. Methods. Twenty male gout patients with …
genetic evidence and national outpatient database. Methods. Twenty male gout patients with …
The impact of long-term biologics/target therapy on bone mineral density in rheumatoid arthritis: a propensity score-matched analysis
JF Chen, CY Hsu, SF Yu, CH Ko, WC Chiu… - …, 2020 - academic.oup.com
Objectives To investigate changes in BMD in RA patients receiving 3-year biological/targeted
synthetic disease-modifying antirheumatic drugs (b/tsDMARD) or conventional synthetic …
synthetic disease-modifying antirheumatic drugs (b/tsDMARD) or conventional synthetic …
[HTML][HTML] Effects of diet control and telemedicine-based resistance exercise intervention on patients with obesity and knee osteoarthritis: a randomized control trial
This study investigated the effects of home-based nutritional and telemedicine-based resistance
exercise interventions on improving body composition, blood biochemistry, and lower-…
exercise interventions on improving body composition, blood biochemistry, and lower-…
Adherence to hydroxychloroquine improves long-term survival of patients with systemic lupus erythematosus
…, HF Lin, YJ Su, YC Chen, JF Chen, TH Chen - …, 2018 - academic.oup.com
Objectives HCQ, which is known to decrease SLE activity, may have a protective effect on
survival, but this has not been proven in Asia. This study aimed to determine whether HCQ …
survival, but this has not been proven in Asia. This study aimed to determine whether HCQ …
Copper(I)-Catalyzed Nitrile-Addition/N-Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6H-indolo[3,2-c]quinolin-6-ones as Potent Topoisomerase-I …
…, YF Chen, CL Chang, SY Chou, SF Chen… - Journal of Medicinal …, 2021 - ACS Publications
In this paper, we present a copper(I)-catalyzed nitrile-addition/N-arylation ring-closure
cascade for the synthesis of 5,11-dihydro-6H-indolo[3,2-c]quinolin-6-ones from 2-(2-bromophenyl)…
cascade for the synthesis of 5,11-dihydro-6H-indolo[3,2-c]quinolin-6-ones from 2-(2-bromophenyl)…