Minimal residual disease (MRD) refers to a chemotherapy/radiotherapy-surviving leukemia
cell population that gives rise to relapse of the disease. The detection of MRD is critical for …

Resistance to multimodal chemotherapy continues to limit the prognosis of acute lymphoblastic
leukemia (ALL). This occurs in part through a process called adhesion-mediated drug …

The interaction between leukemia cells and the bone microenvironment is known to provide
drug resistance in leukemia cells. This phenomenon, called cell adhesion-mediated drug …

Leukemia is an aggressive hematologic neoplastic disease. Therapy-resistant leukemic stem
cells (LSCs) may contribute to the relapse of the disease. LSCs are thought to be protected …

Dysregulated Wnt signaling plays a central role in initiation, progression, and metastasis in
many types of human cancers. Cancer development and resistance to conventional cancer …

Chemotherapy is a critical treatment for endocrine-related cancers; however, chemoresistance
and disease recurrence remain a challenge. The interplay between cancer cells and the …

… Zifeng Zeng, 1 Liwei Xu, 1 Yu Xu, 1 Yongsheng Ruan, 2 Deshen Liu, 1 Jiale Li, 1 Chuanjie
… Zifeng Zeng, Liwei Xu, Yu Xu, and Yongsheng Ruan have contributed equally to this work …

Abstract Treatment of resistant or recurrent acute lymphoblastic leukemia (ALL) remains a
challenge. It was previously demonstrated that the adhesion molecule integrin α4, referred to …

Introduction Since hematopoietic stem cell transplant (HSCT) is an important therapy for
malignant and non-malignant pediatric diseases, improving transplant-related mortality remains …

Cytomegalovirus (CMV) infection remains a critical cause of mortality after allogeneic
hematopoietic stem cell transplantation (allo-HSCT), despite improvement by pre-emptive antivirus …