Background During the spring of 2013, a novel avian-origin influenza A (H7N9) virus emerged
and spread among humans in China. Data were lacking on the clinical characteristics of …

Hemp fibre reinforced unsaturated polyester composites (HFRUPE) were subjected to water
immersion tests in order to study the effects of water absorption on the mechanical …

Background The effects of pharmacological blood pressure lowering at normal or high-normal
blood pressure ranges in people with or without pre-existing cardiovascular disease …

The anticoagulant drug warfarin occurs as a pair of enantiomers that are differentially
metabolized by human cytochromes P450 (CYP). R-warfarin is metabolized primarily by CYP1A2 …

Protein tyrosine phosphatase 1B (PTP1B) is an effective target for the treatment of both type
2 diabetes and obesity; however, targeting PTP1B for drug discovery is challenging because …

Tolbutamide undergoes hydroxylation in humans via a cytochrome P450-mediated pathway.
The primary P450 isozyme responsible for this metabolism is thought to be CYP2C9. …

… Z. Dauter for assistance with data collection, and Dr. M. … Z. Dauter for assistance with data
collection, and Dr. Brenowitz … XG and Z.-YZ are supported in part by the G. Harold and Leila Y…

Novel 3D Ni 1− x Co x Se 2 mesoporous nanosheet networks with tunable stoichiometry are
successfully synthesized on Ni foam (Ni 1− x Co x Se 2 MNSN/NF with x ranging from 0 to …

… In addition, some difluorophosphonate PTP1B inhibitors display insulin mimetic activity in
vivo (ZY. Zhang, unpublished results). On the other hand, since the PTP active site is designed …

Background A vaccine for enterovirus 71 (EV71) is needed to address the high burden of
disease associated with infection. We assessed the efficacy, safety, immunogenicity, antibody …