The term “eosinophilic” asthma (EA) generally refers to the clinical inflammatory phenotype
of asthma wherein a significant number of sputum, airway, and/or blood eosinophils are …

Many patients with breathlessness and chronic obstructive lung disease are diagnosed with
either asthma, COPD, or—frequently—mixed disease. More commonly, patients with …

… AA Zeki has received research support from the NIH, the Tobacco-Related Disease Research
Program and the American Asthma Foundation. M Schivo has received research support …

The cholesterol biosynthesis pathway, also known as the mevalonate (MVA) pathway, is an
essential cellular pathway that is involved in diverse cell functions. The enzyme 3-hydroxy-3-…

The statin drugs (‘statins’) potently inhibit hydroxymethylglutaryl-coenzyme A (HMG-CoA)
reductase by competitively blocking the active site of the enzyme. Statins decrease de novo …

Connective tissue disease (CTD) related interstitial lung disease (CTD-ILD) is one of the
leading causes of morbidity and mortality of CTD. Clinically, CTD-ILD is highly heterogenous …

Rationale: Statin use has been linked to improved lung health in asthma and chronic obstructive
pulmonary disease. We hypothesize that statins inhibit allergic airway inflammation and …

Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease in adults with limited treatment
options. Autophagy and the unfolded protein response (UPR), fundamental processes …

The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the
formation of the intermediate metabolites geranylgeranylpyrophosphate (GGPP) and …

Autophagy, apoptosis, and the unfolded protein response (UPR) are fundamental biological
processes essential for manifold cellular functions in health and disease. Idiopathic …