… Reprinted with permission from Prabhakar SS: Tetrahydrobiopterin reverses the inhibition
of nitric oxide by high glucose in cultured murine mesangial cells. Am J Physiol 281:F179-F188…

Aging is associated with progressive decline in renal function along with concurrent morphological
changes that ultimately lead to glomerulosclerosis. The mechanisms leading to such …

Recombinant human erythropoietin (rHuEPO) is used extensively in anemic patients on
dialysis and other patients and is regarded as very safe and effective in the management of …

Loss of nitric oxide and endothelial derived hyperpolarizing factor mediated responses in
aging. Background Aging has considerable structural and functional effects on the vascular …

… that by the 24th week the ZSF rats had significantly diminished urinary NOx and renal
NOS activities in association with declining GFR and progressive glomerulosclerosis (Prabhakar, …

Macrophage dysfunction is considered an important contributory factor for increased propensity
of infections in uremia. Because nitric oxide (NO) is believed to be an effector molecule …

Alterations of intrarenal nitric oxide (NO) synthesis play an important role in the pathogenesis
and progression of diabetic nephropathy. We tested the hypothesis that hyperglycemia …

Several large-scale clinical studies have consistently demonstrated that use of inhibitors of
renin-angiotensin system such as angiotensin-converting enzyme inhibitors and angiotensin …

… Reprinted from Prabhakar SS, Kidney Int 61:2015–2024, 2001. Permission … Reprinted
from Prabhakar SS, Kidney Int 61:2015–2024, 2001. Permission requested. … SS Prabhakar …

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