Purpose: The Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID), solicits applications for the competitive continuation of a program to study the pathogenesis of acute/early HIV infection in adult humans, and to develop and evaluate the impact of therapeutic interventions at this early stage of HIV disease. This program was initiated under PAR-96-060, Acute Infection and Early Disease Research Network. There are seven current cooperative agreement (U01) awardees; six clinical units and a coordinating center. The goal of this initiative is to maintain a program of five to seven HIV Acute Infection and Early Disease Research Units and one Statistical and Coordinating Center, through cooperative agreements (U01). Each awarded unit will perform innovative, integrated, investigator-initiated pathogenesis and clinical research on acute and early HIV infection and will place emphasis on performing collaborative multi-unit research projects as part of the Acute Infection and Early Disease Research Program (AIEDRP). The multi-unit structure is required in order to enroll sufficient numbers of these difficult-to-identify acutely HIV- infected subjects for study.
Term/Amount: The estimated total funds (direct and Facilities and Administrative (F&A) costs) available for the first year of support for all awards (competitive renewal and new) made under this RFA will be $11.7 million. In Fiscal Year 2002, the NIAID plans to fund approximately 5-7 units and 1 Statistical and Coordinating Center. Although this program is provided for in the financial plans of the NIAID, awards pursuant to this RFA are contingent upon the availability of funds for this purpose and the receipt of a sufficient number of applications of high scientific merit. Funding beyond the first and subsequent years of the grant will be contingent upon satisfactory progress during the preceding years and availability of funds.
Contact: The letter of intent is to be sent to Dr. Hagit David at Division of Extramural Activities, National Institute of Allergy and Infectious Diseases, Room 2152, MSC-7616 6700-B Rockledge Drive, Bethesda, MD 20892-7616 Telephone: (301) 402-4596 FAX: (301) 402-2638 E-Mail: hdavid{at}niaid.nih.gov Applications are to be submitted on the grant application form PHS 398 (rev. 4/98). These forms are available at most institutional offices of sponsored research and from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/435-0714, email: GrantsInfo{at}nih.gov, as well as on the internet at http://grants.nih.gov/grants/forms.htm.
Deadline: Letter of Intent Receipt Date: August 16, 2001. Application Receipt Date: October 10, 2001.