Purpose: The Division of Kidney, Urologic and Hematologic Diseases (DKUHD) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invites cooperative agreement applications to establish a network to design and implement clinical trials to slow the progressive loss of renal function in polycystic kidney disease (PKD). The Network, consisting of a Data Coordinating Center (DCC) and Participating Clinical Centers (PCCs), will develop and execute both pilot and feasibility trials and a large randomized controlled clinical trial on blockade of the renin-angiotensin axis in patients with PKD.
Term/Amount: The NIDDK plans to make four awards for Participating Clinical Centers and one award for a Data Coordinating Center. Approximately $1,500,000 total cost (direct plus facilities and administrative costs) is expected to be available during year one of the study. In all subsequent years $3,000,000 will be available under this RFA. It is anticipated that the award for each Participating Clinical Center will be about $250,000 total cost in year one and $500,000 total cost in all subsequent years. The award for the Data Coordinating Center will be about $500,000 total cost in year one and approximately $1,000,000 total cost in all subsequent years of the program. The number of awards to be made is dependent on the receipt of a sufficient number of applications of high scientific merit and availability of funds. Although this program is provided for in the financial plans of the NIDDK, awards pursuant to this RFA are contingent upon the availability of funds and the receipt of a sufficient number of applications of outstanding scientific and technical merit.
Contact: The letter of intent is to be sent to: Chief, Review Branch Division of Extramural Activities National Institute of Diabetes, Digestive, and Kidney Diseases 6707 Democracy Boulevard, Room 752 Room 752, MSC 5452 Bethesda, Maryland 20892-5452 (for courier service use 20817) Telephone: (301) 594-8885 Fax: (301) 480-3505 Email: fc15y{at}nih.gov Applications must be submitted on the standard research grant application form PHS 398 (rev. 4/98). See “Budget Preparation by Year” section below for additional instructions. Application kits are available at most institutional offices of sponsored research and may be obtained from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, Maryland 20892-7910, telephone (301) 435-0714, E-mail: GrantsInfo{at}nih.gov.
Deadline: Letter of Intent Receipt Date: October 16, 2001. Application Receipt Date: November 16, 2001.