Purpose: The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health invites applications for cooperative agreements to conduct randomized clinical trials (RCTs) to test the effectiveness of interventions delivered in routine clinical practice on achieving weight loss in obese patients who have other cardiovascular risk factors. Routine clinical practice, for the purpose of this request for applications (RFA), is defined as outpatient clinical care delivery and includes primary care settings and relevant specialty settings, such as general internal medicine or cardiology practices. Effectiveness studies focus on interventions that can be easily adapted and adopted in routine clinical practice settings. The results of the studies are expected to be widely disseminated to improve the scientific basis of care for affected individuals.
Term/Amount: The NHLBI intends to commit up to $3 million in FY 2006 to fund three to five RCTs in response to this RFA. The maximum amount for each RCT for 5 years will be $3,550,000 in direct costs. Each applicant may request a project period of 5 years and a budget for direct costs of up to $500,000 for the first year, $850,000 for the second year, $850,000 for the third year, $850,000 for the fourth year, and $500,000 for the fifth year. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. Although the financial plans of the NHLBI provide support for this program, awards pursuant to this RFA are contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications. A total of up to $20 million is available from NHLBI over the 5-year period for the project. It is anticipated that the maximum award for the resource and coordination functions will be approximately $675,000 in direct costs, including direct costs of up to $150,000 for the first year, $125,000 for the second year, $125,000 for the third year, $125,000 for the fourth year, and $150,000 for the fifth year. The RCF costs are in addition to the RCT costs.
Deadlines: Letter of intent receipt date: January 17, 2006; application receipt date: February 15, 2006.
Complete details are available at http://grants1.nih.gov/grants/guide/rfa-files/RFA-HL-06-007.html.