A
Acute emphysema, a G-protein coupled LPA2 deficient mice, sepsis induces, 19
Acute insulin release (AIR), comparison with the minimal model analysis of an intravenous glucose tolerance test in African American men, 80
Acute lung injury
pathologic cyclic stretch-derived endothelial microparticles induce, 104
sphingosine 1-phosphate receptor 1 associated with human susceptibility to severe sepsis- induced, 88
transcriptional regulation of pre-B cell colony enhancing factor gene by, 30
Acute myocardial infarction, mitral valve papillary fibroelastoma, 35
Acute pancreatitis, hospitalized children in the United States from 2000–2009, epidemiology of, 63
Adipose triacyglycerol lipase (ATGL)
effects of FOXO1 on hepatic triacylglycerol turnover, lipogenic gene expression and vldl secretion, 74
effects of foxo1 on hepatic triacylglycerol turnover, lipogenic gene expression and VLDL secretion, 74
African American men (AAM)
comparison with the minimal model analysis of an intravenous glucose tolerance test in, 80
veterans with pre-diabetes have low dietary vitamin d and high fat intake, 82
with pre-diabetes have low dietary vitamin D and high fat intake, 82
AKT/MTOR pathway, contributes to enhanced pulmonary artery smooth muscle cell proliferation in patients and animals with pulmonary arterial hypertension, activation of, 60
Aldosterone, preeclampsia, suppression of progesterone and, 17
Antioxidant regulation, role of MIF in age-related susceptibility to radiation lung injury via NRF2 and, 87
Apoptosis, cholecystokinin protects pancreatic beta cells from, 106
Arterio-venous hemodialysis graft, recalcitrant, multiple antibiotics-resistant staphylococcus epidermidis bacteremia resolving upon ligation of, 109
B
β-cell failure
interplay between genotype, temporal phase, and age in, 90
interplay between genotype, temporal phase, and age in circadian-induced diabetes mellitus and, 90
Bio-plexTM Pro assay (Bio-rad), interleukin 7 (IL7) and IL7 receptors are the mediators in the development of pulmonary hypertesnion in humans and mice, 8
Bone mineral density, fat-bone interaction may result in subclinical steato-osteomyelitis and, 86
C
C-ABL inhibition, barrier function in stretched pulmonary endothelium and exacerbates mechanical ventilation-induced murine acute lung injury, disrupts, 100
Cannabinoids, data base assists in answering clinically relevant questions, 102
Cardiac Na+ current (INa), a mechanism for rescuing reduced, 32
Cardiac power output (CPO)
comparison of pulmonary artery catheter and transthoracic echocardiographic assessment and analysis of trend in critically ill surgical patients, 16
pulmonary artery catheter and transthoracic echocardiographic assessment and analysis, of trend in critically ill surgical patients, comparison, 16
Cardiomyopathy, particulate matter exacerbates lung inflammation in mice with, 25
Cardiovascular disease (CVD), subclinical disease prevalence and risk of cardiovascular events in African Americans with and without diabetes, comparision, 110
CD44, novel regulator of oxidized phospholipids-mediated RAC1 activation in caveolin-enriched microdomains and pulmonary endothelial barrier enhancement, 89
Cell lung cancer, SNPS in myosin light chain kinase pseudogene contribute to, 1
Cellular tropism, dengue virus infection in human lung, 52
Cholecystokinin (CCK), protects pancreatic beta cells from apoptosis, 106
Cholecystokinin, protects pancreatic beta cells from apoptosis, 106
Cilia, a barrier to diffusion of opsins but not peripheral membrane proteins at the connecting cilium and disk rims, 7
Circadian-induced diabetes mellitus, interplay between genotype, temporal phase, and age in, 90
Clostridium difficile, community-associated infection and antibiotics, 50
Coagulopathy, independent predictor of in-hospital mortality among patients undergoing transjugular liver biopsy, 68
Cochlear implants, in older adults, long-term use of, 45
D
Deep vein thrombosis
consequences of failing to investigate for familial or acquired thrombophilia after deep vein thrombosis, 26
exogenous testosterone therapy in men and women with previously undiagnosed thrombophilia or hypofibrinolysis, 83
Dengue hemorrhagic fever (DHF), is cellular tropism responsible for the pathophysiology of, 52
Dengue virus infection, is cellular tropism responsible for the pathophysiology of, 52
Diabetes (DM)
comparison of subclinical disease prevalence and risk of cardiovascular events in African Americans with and without, 110
concordance between the estimated hemoglobin A1C derived from short term continous glucose monitoring system mean glucose level and the measured hemoglobin A1C in subjects with, 77
subclinical disease prevalence and risk of cardiovascular events in African Americans with and without diabetes, comparision, 110
Disposition index (DI), comparison with the minimal model analysis of an intravenous glucose tolerance test in African American men, 80
DNA methylome, of fibroblasts from patients with idiopathic pulmonary fibrosis, alterations in, 46
Drosophila melanogaster balancer chromosomes, assembly and analysis of inversion breakpoints in, 42
E
Ejection fraction, searching for biomarkers in heart failure with preserved, 57
Enalapril, mitigate radiation nephropathyclinically relevant doses of, 76
Endocrine disruptor tolylfluanid , global energy metabolism, effects of, 103
Endothelial apoptosis, NADPH oxidase 4 regulates pseudomonas aeruginosa-induced permeability and, 70
Endothelial barrier function, the crucial role of pecam1 induced by simvastatin for, 41
eNOS T786C mutation, a treatable etiology for prinzmetal’s angina, 61
Ethyroid sick
explained hypotension in the intensive care unit, 51
unexplained hypotension in the intensive care unit, 107
F
Familial thrombophilia
consequences of failing to investigate for familial or acquired thrombophilia after deep vein thrombosis, 26
sudden sensorineural hearing loss and, 10
FOXO1, impairs glucose tolerance and promotes insulin resistance in liver-specific insulin receptor knockout (LIRKO) mice, 71
FTY720 S-phosphonate, cytoskeletal and junctional complex rearrangement mediates pulmonary endothelial barrier enhancement by, 29
G
G0S2
effects of foxo1 on hepatic triacylglycerol turnover, lipogenic gene expression and VLDL secretion, 74
GCK, maturity-onset diabetes of the young (MODY), in the US monogenic diabetes registry, 96
Glucocorticoids
microrna-based approach expands on genome-wide association study and identifies SNPS important for response, 6
microRNA-based approach expands on genome-wide association study and identifies SNPS important for response to, 6
Group B streptococcal colonization, outcomes of alternative antibiotic regimen in penicillin allergic pregnant women with, 94
Group B streptococcal infection, outcomes of alternative antibiotic regimen in penicillin allergic pregnant women, 94
H
HDL cholesterol, cardiovascular events in 190 patients, who had 5 years follow-up, and median age 84 years at last follow-up, 81
Heart failure, a mechanism for rescuing reduced cardiac Na+ current in, 32
Hemoglobin A1C, concordance between the estimated hemoglobin A1C derived from short term continous glucose monitoring system mean glucose level and the measured in diabetes, 77
Henoch-Schönlein purpura, fever of unknown origin in a 12 month old boy, 24
Hepatic triacylglycerol turnover, effects of foxo1 on lipogenic gene expression, VLDL secretion and, 74
Hereditary thrombophilia, multifocal osteonecrosis and, 20
HIV patients, deficient reporting and interpretation of non-inferiority randomized clinical trials in, 48
HIV/AIDS, data base assists in answering clinically relevant questions, 102
HNF1A, maturity-onset diabetes of the young (MODY), in the US monogenic diabetes registry, 96
Human embryonic stem cells (hESCs), computationally informed identification of pancreatic islet maturation pathways, 56
Hyaluronan, extracellular vesicle release from caveolin-enriched microdomains regulates sustained human pulmonary vascular integrity, 92
Hyperoxaluria, relevance to calcium oxalate kidney stone disease, 108
Hypofibrinolysis, treatable etiologies of osteonecrosis of the knee, 84
Hypoxia-mediated pulmonary hypertension (HPH), interleukin 7 (IL7) and IL7 receptors are the mediators in the development of pulmonary hypertesnion in humans and mice, 8
I
Idiopathic pulmonary fibrosis, alterations in the DNA methylome of fibroblasts from patients with, 46
IL7 receptor, mediators in the development of pulmonary hypertesnion in humans and mice, Interleukin-7 (IL7) and, 8
IL7, and interleukin 7 (IL7) mediators in the development of pulmonary hypertesnion in humans and mice, 8
Indwelling venous catheter (IVC), influence of indication of catheter placement on microbiology of, 72
Insulin resistance, 13C-glocose breath testing provides a non-invasive measure of, 31
Insulin sensitivity (SI), comparison with the minimal model analysis of an intravenous glucose tolerance test in African American men, 80
Integrin b4
central part role in cyclic stretch-induced endothelial cell inflammatory responses, 44
cyclic stretch-induced endothelial cell inflammatory responses, role of, 44
Interleukin 6, acute lung injury in mice, 62
Interleukin 7 (IL7)
and IL7 mediators in the development of pulmonary hypertesnion in humans and mice, 8
Interleukin-7 (IL7), mediators in the development of pulmonary hypertesnion in humans and mice, IL7 receptor and, 8
Intracardiac thrombus, myocardial infarction, and familial thrombophilia, 58
Intravenous glucose tolerance test (IVGTT), comparison with the minimal model analysis of an intravenous glucose tolerance test in African American men, 80
IPEX syndrome, FOXP3 mutations causing neonatal diabetes without classic features of, 59
J
Jackson heart study, comparison of subclinical disease prevalence and risk of cardiovascular events in African Americans with and without diabetes, 110
JCV T-antigen, hypoxia and glucose deprivation in medulloblastoma, 3
K
Kidney stone disease, mechanisms of obesity-associated hyperoxaluria, 108
Kinetochore-microtubules, radiation-induced genome damage, mediates, 5
L
LDL cholesterol, cardiovascular events in 190 patients, who had 5 years follow-up, and median age 84 years at last follow-up, 81
Leptin, alternate day fasting when combined with endurance exercise reduces, 11
Lung cancer, non-muscle myosin light chai kinase related genes predicts clinical outcome in, 54
Lung endothelial cell, elastic properties and gap closure in response to barrier-regulatory agonists, characterization of, 14
Lung epithelia cell migration, F-box protein degradation cascade regulates, 21
Lysophosphatidic acid receptor 2 deficiency, bleomycin-induced lung injury and fibrosis in mice, protects against, 34
M
Maturity-onset diabetes of the young (MODY), in the US monogenic diabetes registry, 96
Metabolic syndrome (MetS), fat-bone interaction may result in subclinical steato-osteomyelitis and decreased bone mineral content in African American men with, 86
Microbial translocation (LPS), strongly predict excessive alcohol consumption, serum markers of immune response (SCD14 AND SCD163) and, 95
MicroRNA-130A, regulation of connexin43 and arrhythmogenesis by, 43
Mitochondrial oxidative stress (mitoROS)
a mechanism for rescuing reduced cardiac Na+ current in heart failure, 32
IL-13 mediated TGFb secretion is dependent on, 85
Mouse insulin promotor (MIP), cholecystokinin protects pancreatic beta cells from apoptosis, 106
Multifocal osteonecrosis, hereditary thrombophilia and, 20
Multiple sclerosis, genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and, 91
Murine acute lung injury, C-ABL inhibition disrupts barrier function in stretched pulmonary endothelium and exacerbates mechanical ventilation-induced, 100
Myocardial infarction (MI), subclinical disease prevalence and risk of cardiovascular events in African Americans with and without diabetes, comparision, 110
Myocyte contractility, transient receptor potential vanilloid 2 mediates, 40
Myopericarditis, Still’s disease presenting with, 101
Myosin light chain kinase, allergic inflammation in a murine model of asthma, regulates, 28
N
NADH, a mechanism for rescuing reduced cardiac Na+ current in heart failure, 32
NADPH oxidase 4, pseudomonas aeruginosa-induced endothelial apoptosis and permeability, regulates, 70
NCC, via a spak-mediated pathway, acute aldosterone affects, 2
Nematode asparaginyl TRNA synthetase, intestinal inflammation in mice with Tcell transfer colitis, resolves, 36
Nephrotic syndrome, caused by chronic graft versus host disease-is it real?, 38
Non-inferiority randomized clinical trials, HIV patients, deficient reporting and interpretation of, 48
Non-muscle myosin light chain kinase isoform (nmMLCK), related genes predicts clinical outcome in lung cancer, 54
NRF2, role of MIF in age-related susceptibility to radiation lung injury via antioxidant regulation and, 87
O
Obese adults
alternate day fasting with a high fat diet, 9
rage expression in human skeletal muscle is normalized following aerobic exercise training in older, 69
Obesity, relevance to calcium oxalate kidney stone disease, 108
Ocular thrombosis, a window to familial thrombophilia, 55
Oral glucose tolerance test, comparison with the minimal model analysis of an intravenous glucose tolerance test in African American men, 80
Osteonecrosis, exogenous testosterone therapy in men and women with previously undiagnosed thrombophilia or hypofibrinolysis, 83
P
Pancreatic b-cells
cholecystokinin protects from apoptosis, 106
insulin signaling modulates proinsulin processing by regulating translation initiation in, 53
Pancreatic islet maturation pathways, computationally informed identification of, 56
Pediatric inflammatory bowel disease, results from a United States database 2000–2009, trends in, 66
Perinatal hyperthyroidism, MCT8 deficient mice, 105
Polycystic ovary syndrome (PCOS), treatable determinants of high ALT and AST in, 67
Polymorphisms, function analysis of myosin light chain kinase gene promoter and inflammatory lung disease associated, 23
Preeclamsia, a translational approach with patients, a rat model and in vitro studies, 15
Progesterone , preeclampsia, suppression of aldosterone and, 17
(Pro)renin, a translational approach with patients, a rat model and in vitro studies, 15
Protein kinase C, delta-mediated regulation of thrombin-induced human lung endothelial cell barrier disruption, mechanisms of, 47
Pulmonary arterial hypertension, activation of AKT/MTOR pathway contributes to enhanced pulmonary artery smooth muscle cell proliferation in patients and animals with, 60
Pulmonary artery catheter (PAC), and transthoracic echocardiographic assessment and analysis of trend in critically ill surgical patients, comparison, 16
Pulmonary artery smooth muscle cell (PASMC), interleukin 7 (IL7) and IL7 receptors are the mediators in the development of pulmonary hypertesnion in humans and mice, 8
Pulmonary embolism, exogenous testosterone therapy in men and women with previously undiagnosed thrombophilia or hypofibrinolysis, 83
Pulmonary endothelium, group v phospholipase A2(GVPLA2) increses permeability and cytokine release in, 27
Pulmonary fibrosis
inhibition of RAC1 gerarnylgeranylation prevents the development of, 78
redox regulation of STAT6 is linked to development of, 79
Pulmonary vascular resistance, a novel method of noninvasive estimation and association with mortality in crtically ill surgical patients, 13
R
RAC1 gerarnylgeranylation, the developmentof pulmonary fibrosis by attenuating mitochondrial oxidative stress, prevents, 78
RAC1, SCF E3 ligase F-box protein complex SCFFBXL19 regulates, ubiquitination and degradation, 18
Rapamycin
increased accumulation of immature autophagosomes, 22
tauopathy is associated with increased accumulation of immature autophagosomes, 22
Retinal ganglion cells, TGFb signaling induces expression of GADD45B in, 37
Retinal vein thrombosis, consequences of failing to investigate for familial or acquired thrombophilia after deep vein thrombosis, 26
S
Sarcoidosis, ocular and renal involvement as the rare initial manifestation of, 98
Serotonin type 4 receptor, angiogenesis in mouse ischemic hindlimb, 33
Serum homocysteine levels, within the broad range of normal renal function, serum creatinine is an independent predictor of, 65
Sick hypothyroid
explained hypotension in the intensive care unit, 51
unexplained hypotension in the intensive care unit, 107
Simvastatin, cyclic stretch-induced endothelial cell inflammatory responses, 44
Sodium chloride cotransporter (NCC), acute aldosterone affects, 2
Spak-mediated pathway, acute aldosterone affects NCC via a, 2
Spondyloarthropathy, whole body magnetic resonance imaging in evaluation of enthesitis in, 39
Staphylococcus aureus bacteremia, mortality from methicillin-resistant, 49
Statins do not mitigate radiation nephropathy, 75
Steato-osteomyelitis, fat-bone interaction may result in subclinical bone mineral density and, 86
Still’s disease, presenting with myopericarditis, 101
Subclinical disease (ScD), subclinical disease prevalence and risk of cardiovascular events in African Americans with and without diabetes, comparision, 110
Sudden sensorineural hearing loss, familial thrombophilia and, 10
Sulfonylureas, successful switch from insulin, KATP channel-related neonatal diabetes, 73
Systemic lupus erythematosus, genetic variation near IRF8 is associated with serologic and cytokine profiles in multiple sclerosis and, 91
T
T cell transfer colitis, nematode asparaginyl TRNA synthetase resolves intestinal inflammation in mice with, 36
Tauopathy, increased accumulation of immature autophagosomes, 22
Tcell transfer colitis, nematode asparaginyl TRNA synthetase resolves intestinal inflammation in mice with, 36
Thrombophilia
deep vein thrombosis followed by retinal vein thrombosis in familial thrombophilia, 26
treatable etiologies of osteonecrosis of the knee, 84
Thrombophilia
multifocal osteonecrosis and hereditary, 20
sudden sensorineural hearing loss and familial, 10
treatable etiologies of osteonecrosis of the knee, 84
Thrombosis, treatable high homocysteine is often the sole thrombophilia associated with, 11, 12
Transjugular liver biopsy, coagulopathy is an independent predictor of in-hospital mortality among patients undergoing, 68
Transthoracic echocardiography (TTE), and pulmonary artery catheter assessment and analysis of trend in critically ill surgical patients, comparison, 16
Triglycerides, cardiovascular events in 190 patients, who had 5 years follow-up, and median age 84 years at last follow-up, 81
Trypanosoma cruzi, infection and vaccination on priming T. cruzi-specific CD4 T cells, the effects of, 64
Type 1 diabetes, insulin resistance in premenopausal women with, 97
Type 2 diabetes, with pre-diabetes have low dietary vitamin D and high fat intake, 82
V
Vitamin D, similarities and differences between patients included and excluded from a randomized clinical trial , supplementation for improving glucose tolerance in prediabetes, 99
vWF secretion, G12-dependent constitutive and evoked endothelial cell, 93
W
Whole-cell patch clamp record, a mechanism for rescuing reduced cardiac Na+ current in heart failure, 32