TROPICAL MEDICINE RESEARCH CENTERS (P50): RFA-AI-06-006
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Letters of intent receipt date: June 21, 2006
Application receipt date: July 21, 2006
The NIAID invites applications for Tropical Medicine Research Centers (TMRC). Each Center must be located in a geographic area where at least one of the following diseases is endemic: leishmaniasis, Chagas' disease, and human African trypanosomiasis. The focus of the application should be on only one of these diseases. The total funding available for this program is $2.6 million per year for 5 years. It is anticipated that three to four awards will be made. The mechanism of support will be the Specialized Center grant (P50). The P50 supports multiproject grants in which all of the projects are interrelated to a common goal. The TMRC must have at least two interrelated research projects, one of which must be a clinical study. Clinical trials are not allowed. In addition, the TMRC must have an administrative core and a data management core. Only non-US organizations and institutions located in areas endemic for leishmaniasis, Chagas' disease, or human African trypanosomiasis are eligible to apply. Applications may be submitted by for-profit and not-for-profit organizations; public and private institutions, such as universities, colleges, hospitals, and laboratories; and government agencies in the endemic country. The TMRC must be located in a politically stable setting where there are no unusual safety or security threats. The country where the TMRC is being proposed should not have a history of protracted US State Department warnings. Eligible principal investigators include individuals with the skills, knowledge, and resources necessary to carry out the proposed research and to work with their institution to develop an application for support. The TMRC will be headed by a program director, who shall commit at least 40% effort to the project and who must serve as project leader on one of the research projects. An institution may submit only one application in response to this request for applications.
Complete details are available at <http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-06-006.html>.
NHLBI INNOVATIVE RESEARCH GRANT PROGRAM (R21): PA-06-239
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Opening date: May 2, 2006 (earliest date an application may be submitted to Grants.gov)
Application submission date(s): standard dates apply; please see <http://grants1.nih.gov/grants/funding/submissionschedule.htm>
This funding opportunity announcement (FOA) solicits exploratory/developmental (R21) grant applications from applicant organizations that propose innovative and potentially high-impact studies that make use of existing data sets or existing collections of biologic specimens from human subjects. Awards made in this program may be used to support the addition and analyses of elements of existing data sets and existing specimen collections to the extent feasible within the time and dollar limits of the program. Primary emphasis, however, must involve the use of existing data from human studies or existing collections of human biologic specimens. Proposed studies are expected to provide preliminary results to demonstrate the feasibility of novel approaches to heart, lung, and blood diseases and sleep disorders. The number of awards made under this solicitation will depend on the overall scientific merit of the applications and the availability of funds. This FOA will use the exploratory/developmental (R21) grant mechanism. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend on the mechanism numbers, quality, duration, and costs of the applications received. The total project period for an application submitted in response to this funding opportunity may not exceed 2 years. Direct costs are limited to $275,000 over an R21 2-year period, with no more than $200,000 in direct costs allowed in any single year. Eligible organizations include for-profit organizations; nonprofit organizations; public or private institutions, such as universities, colleges, hospitals, and laboratories; units of state government; units of local government; eligible institutions of the federal government; domestic institutions; foreign institutions; faith- or community-based organizations; units of state tribal government; and units of local tribal government. Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups and individuals with disabilities are always encouraged to apply for NIH support. Applicants may submit more than one application provided that each application is scientifically distinct. An R21 is not renewable. All exploratory/developmental grant applications received in response to this announcement will be assigned to the NHLBI.
The SF424 (R&R) application guide for this FOA is located at these Web sites:
http://grants1.nih.gov/grants/funding/424/SF424-RR-Guide-General.doc
http://grants1.nih.gov/grants/funding/424/SF424-RR-Guide-General.pdf
NOTICE: Applications submitted in response to this FOA for federal assistance must be submitted electronically through Grants.gov (<http://www.grants.gov>) using the SF424 research and related (R&R) forms and the SF424 (R&R) application guide. Applications may not be submitted in paper format. A registration process is necessary before submission, and applicants are highly encouraged to start the process at least 4 weeks prior to the grant submission date.
Complete details are available at <http://grants.nih.gov/grants/guide/pa-files/PA-06-239.html>.
NETWORK FOR CARDIOTHORACIC SURGICAL INVESTIGATIONS IN CARDIOVASCULAR MEDICINE (U01): RFA-HL-06-005
National Institutes of Health (NIH)
Canadian Institutes of Health Research (CIHR)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Neurological Disorders and Stroke (NINDS) Institute of Circulatory and Respiratory Health (ICRH)
Letters of intent receipt date: July 28, 2006
Application receipt date: August 28, 2006
The NIH and the CIHR invite applications to participate in the Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine (Network), a cooperative network of academic centers with clinically active cardiothoracic surgeons and their colleagues in allied specialties interested in promulgating the use of evidence-based medicine in surgical practice. The goal of the Network is to foster a culture of rigorous scientific comparisons and promote the evaluation of newer surgical techniques, technologies, devices, and innovative pharmaceutical and bioengineered products directed at cardiovascular disease. The Network will allow research teams led by cardiac surgeons to evaluate, by the most rigorous methods possible, newer therapies and techniques as they move from laboratory science to broad clinical use. The Network will enhance the capacity to disseminate study results and translate findings to large-scale trials or practice. The program will provide support to maintain the necessary infrastructure to develop, coordinate, and conduct multiple collaborative proof-of-concept clinical studies and interventional protocols to improve cardiovascular disease outcomes. Up to seven awards will be made for Clinical Centers and one award for a Data Coordinating Center. Approximately $35 million (total costs) over 5 years will be awarded, with $5 million in the first year. It is anticipated that the annual award for the Data Coordinating Center will be approximately $1.1 million for direct costs in the first year and $1.4 million each year for years 2 through 5. The maximum annual amount for each Clinical Center will be $250,000 for direct costs. An additional budget of $13.2 million for protocols and related patient costs for the entire 5-year study period is anticipated. A maximum of two Clinical Skills Development Core awards will be made for up to $100,000 per year (direct costs). The cooperative agreement (U01) administrative and funding mechanism of support will be used. Eligible organizations include domestic or Canadian institutions; for profit and nonprofit organization; public and private institutions, such as universities, colleges, hospitals, and laboratories; faith- or community-based organizations; units of state tribal government; units of local tribal government; and eligible agencies of the federal government. Eligible principal investigators include those with the experience and expertise to conduct clinical studies evaluating cardiothoracic surgical interventions and other therapies directed at cardiovascular disease. A presubmission meeting will be held on Wednesday, May 3, 2006, from 12:00 to 2:00 pm in Philadelphia, Pennsylvania, at the American Association of Thoracic Surgeons Meeting site. Additional details will be posted at a later date on the Network Web site (<http://www.nhlbi.nih.gov/funding/inits/surgnetwork-faq.htm>).
Awards for a Clinical Center and a Data Coordinating Center will not be made to the same principal investigator to ensure that data analysis is performed independently of data acquisition. The same institution may apply for both a Clinical Center and the Data Coordinating Center award, but the applications for each must be from different individuals and must be submitted as separate applications. A set of frequently asked questions (FAQs) will be developed and posted at the additional information site: <http://www.nhlbi.nih.gov/funding/inits/surgnetwork-faq.htm>.
Complete details are available at <http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-06-005.html>.
NIDCR EXPLORATORY AND DEVELOPMENTAL GRANTS IN CLINICAL RESEARCH (R21): PAR-06-246
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
Opening date: May 2, 2006 (earliest date an applicationmay be submitted to Grants.gov)
Application submission date(s): standard dates apply; please see <http://grants.nih.gov/grants/funding/submissionschedule.htm>
The goal of this announcement is to broadly encourage developmental, exploratory, or pilot clinical research to (1) document oral conditions and risk factors for oral and craniofacial diseases and disorders; (2) investigate new methods of diagnosing oral disease; (3) address behavioral and health promotion topics relevant to oral health, dental care, or oral health promotion; and/or (4) identify promising culturally appropriate approaches to prevent and reduce oral health disparities. This funding opportunity announcement (FOA) will use the NIH exploratory/developmental (R21) award mechanism. The NIDCR does not have set-aside funds for this FOA, and because the nature and scope of the proposed research will vary from research is invited to work with his or her institution to develop an application for support. Individuals from underrepresented racial and ethnic groups and individuals with disabilities are always encouraged to apply for NIH support. Applicants may submit more than one application provided that each application is scientifically distinct. An R21 grant is not renewable.
The SF424 (R&R) application guide for this FOA is located at these Web sites:
<http://grants.nih.gov/grants/funding/424/SF424-RR-Guide-General.doc>
<http://grants.nih.gov/grants/funding/424/SF424-RR-Guide-General.pdf>
For general information on SF424 (R&R) application and electronic submission, see the following Web sites:
SF424 (R&R) application and electronic submission information:
<http://grants.nih.gov/grants/funding/424/index.htm>
General information on electronic submission of grant applications:
<http://era.nih.gov/ElectronicReceipt/>
NOTICE: Applications submitted in response to this FOA for federal assistance must be submitted electronically through Grants.gov (<http://www.grants.gov>) using the SF424 research and related (R&R) forms and SF424 (R&R) application guide. Applications may not be submitted in paper format. A registration process is necessary before submission, and applicants are highly encouraged to start the process at least 4 weeks prior to the grant submission date.
Complete details are available at <http://grants.nih.gov/grants/guide/pa-files/PAR-06-246.html>.
NCI COMPETITIVE SUPPLEMENTS FOR PILOT PROJECTS FOR COMMUNITY NETWORKS PROGRAM TO REDUCE CANCER HEALTH DISPARITIES (U01): RFA-CA-06-504
National Institutes of Health (NIH)
National Cancer Institute (NCI)
The purpose of this request for applications (RFA) is to enable NCI Community Network Program (CNP) grantees to submit competitive supplements for pilot projects as part of the CNP RFA-CA-05-012 requirements. The NCI intends to commit approximately $2,000,000 in FY 2006 to fund up to 27 competitive supplements in response to this announcement. This funding opportunity will use the NIH Competitive Supplement award mechanism to supplement existing, funded (U01) CNP awards. Eligible institutions or organizations are the current CNP awardees (institutions/organizations) that have approval to transition their CNP to phase II. Eligible principal investigators (PIs) are the current CNP awardees (PIs) who have approval to transition their CNP to phase II. Coinvestigators, who may conduct pilot projects, are “new” investigators (see < http://grants.nih.gov/grants/guide/notice-files/not97-231.html> for the definition of new investigator); they include any individual with the skills, knowledge, and resources necessary to carry out the proposed research and are invited to work with the PI to develop an application for support. Individuals from racial or ethnic minorities and underserved populations and individuals with disabilities are always encouraged to apply for NIH programs. Each CNP awardee (PI) may submit up to four separate supplement applications.
The application form is available at <http://grants.nih.gov/grants/funding/phs398/phs398.html>.
Complete details are available at <http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-06-504.html>.
COMPETITIVE CONTINUATION OF CENTERS OF BIOMEDICAL RESEARCH EXCELLENCE (COBRE) (P20): RFA-RR-06-001
National Institutes of Health (NIH)
National Center for Research Resources (NCRR)
Application receipt date: August 10, 2006
The NCRR of the NIH invites applications for competing continuation of eligible Centers of Biomedical Research Excellence (COBRE) grants. The objective of the COBRE initiative is to strengthen an institution's biomedical research infrastructure through the establishment of a thematic multidisciplinary center and to enhance the ability of investigators to compete independently for complementary NIH individual research grant or other external peer-reviewed support. COBRE awards are supported through the Institutional Development Award (IDeA) Program, which aims to foster health-related research by increasing the competitiveness of investigators at institutions located in states with historically low aggregate success rates for grant awards from the NIH. The NCRR intends to commit approximately $18 million in FY 2007 to support this initiative. It is anticipated that up to 10 competing continuation applications will be funded in response to this request for applications (RFA). Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. Although the financial plans of the Institutes and Centers provide support for this program, awards pursuant to this funding opportunity are contingent on the availability of funds and the receipt of a sufficient number of meritorious applications. This RFA will use the NIH exploratory grant mechanism (P20). Eligibility is restricted to (1) institutions awarded a COBRE grant in response to RFA RR-02-003 (<http://grants.nih.gov/grants/guide/rfa-files/RFA-RR-02-003.html>), (2) institutions awarded a COBRE grant in response to RFA RR-00-006 (<http://grants.nih.gov/grants/guide/rfa-files/RFA-RR-00-006.html>) but not awarded a competitive continuation in response to Notice (NOT) RR-05-007 (<http://grants.nih.gov/grants/guide/notice-files/NOT-RR-05-007.html>), and (3) institutions awarded a COBRE grant in response to RFA RR-00-003 (<http://grants.nih.gov/grants/guide/rfa-files/RFA-RR-00-003.html>) but not awarded a competitive continuation in response to NOT RR-05-007 (<http://grants.nih.gov/grants/guide/notice-files/NOT-RR-05-007.html>). Either the current principal investigator (PI) or a new PI with the skills, knowledge, and resources necessary to carry out the proposed research may be selected by the institution to develop an application for continuation support. The PI of the COBRE application must be an established biomedical or behavioral research scientist who has demonstrated the administrative abilities to effectively carry out the objectives of the COBRE program and meet its goals. Applicants may submit only one application in response to this RFA.
Complete details are available at <http://grants.nih.gov/grants/guide/rfa-files/RFA-RR-06-001.html> (see Section IV.1 for application materials).
PROGRAM PROJECTS FOR BASIC RESEARCH ON HUMAN EMBRYONIC STEM CELLS (P01): RFA-GM-07-00
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Letters of intent receipt date: September 6, 2006
Application receipt date: October 6, 2006
The goal of the proposed program project (P01) grants is to support research on the basic biology of human embryonic stem cells (hESCs) and to promote the use of hESCs as a model system to address significant questions in the basic biomedical sciences. The P01 should include a minimum of three R01-like subprojects to study the unique characteristics of hESCs and/or to use hESCs as a model system to address a basic biologic question. The P01 should include a core to grow, maintain, and further characterize approved hESC lines listed on the NIH Human Embryonic Stem Cell Registry, <http://stemcells.nih.gov/research/registry/>. In addition, the core should serve as a resource to train investigators at the grantee institution to work with and use hESCs in pilot experiments. The core may also support research on improved growth and culture conditions of hESCs, compare the characteristics of hESC lines, and develop reagents and tools to enhance the use of hESCs as an experimental model system. The maximum amount to be awarded for each application is $6.1 million, direct costs, for 5 years, and it is anticipated that up to four awards will be made. This request for applications uses the P01 program project mechanism. Eligible organizations include nonprofit organizations; public or private institutions, such as universities, colleges, hospitals, and laboratories; units of state government; units of local government; eligible agencies of the federal government; and domestic institutions. Eligible principal investigators include any individual with the skills, knowledge, and resources necessary to carry out the proposed research. Individuals from underrepresented racial and ethnic groups and individuals with disabilities are always encouraged to apply for NIH programs. Applicants may submit more than one application provided that they are scientifically distinct.
Complete details are available at <http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-07-002.html>.