Open Access
ALLY in fighting COVID-19: magnitude of albumin decline and lymphopenia (ALLY) predict progression to critical disease
Johanna S van Zyl, Amit Alam, Joost Felius, Ronnie M Youssef, Dipesh Bhakta, Christina Jack, Aayla K Jamil, Shelley A Hall, Göran B Klintmalm, Cedric W Spak, Robert L Gottlieb
DOI: 10.1136/jim-2020-001525 Published 4 March 2021
Johanna S van Zyl
1
Baylor Scott & White Research Institute, Baylor Scott and White Health, Dallas, Texas, USA
2
Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, Texas, USA
3
Baylor Annette C and Harold C Simmons Transplant Institute, Baylor Scott and White Health, Dallas, Texas, USA
4
College of Medicine, Texas A&M Health Science Center, Texas A&M University, Dallas, Texas, USA
Amit Alam
1
Baylor Scott & White Research Institute, Baylor Scott and White Health, Dallas, Texas, USA
2
Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, Texas, USA
3
Baylor Annette C and Harold C Simmons Transplant Institute, Baylor Scott and White Health, Dallas, Texas, USA
4
College of Medicine, Texas A&M Health Science Center, Texas A&M University, Dallas, Texas, USA
Joost Felius
1
Baylor Scott & White Research Institute, Baylor Scott and White Health, Dallas, Texas, USA
2
Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, Texas, USA
3
Baylor Annette C and Harold C Simmons Transplant Institute, Baylor Scott and White Health, Dallas, Texas, USA
4
College of Medicine, Texas A&M Health Science Center, Texas A&M University, Dallas, Texas, USA
Ronnie M Youssef
4
College of Medicine, Texas A&M Health Science Center, Texas A&M University, Dallas, Texas, USA
Dipesh Bhakta
4
College of Medicine, Texas A&M Health Science Center, Texas A&M University, Dallas, Texas, USA
Christina Jack
4
College of Medicine, Texas A&M Health Science Center, Texas A&M University, Dallas, Texas, USA
Aayla K Jamil
1
Baylor Scott & White Research Institute, Baylor Scott and White Health, Dallas, Texas, USA
2
Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, Texas, USA
3
Baylor Annette C and Harold C Simmons Transplant Institute, Baylor Scott and White Health, Dallas, Texas, USA
4
College of Medicine, Texas A&M Health Science Center, Texas A&M University, Dallas, Texas, USA
Shelley A Hall
1
Baylor Scott & White Research Institute, Baylor Scott and White Health, Dallas, Texas, USA
2
Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, Texas, USA
3
Baylor Annette C and Harold C Simmons Transplant Institute, Baylor Scott and White Health, Dallas, Texas, USA
4
College of Medicine, Texas A&M Health Science Center, Texas A&M University, Dallas, Texas, USA
Göran B Klintmalm
1
Baylor Scott & White Research Institute, Baylor Scott and White Health, Dallas, Texas, USA
3
Baylor Annette C and Harold C Simmons Transplant Institute, Baylor Scott and White Health, Dallas, Texas, USA
4
College of Medicine, Texas A&M Health Science Center, Texas A&M University, Dallas, Texas, USA
Cedric W Spak
1
Baylor Scott & White Research Institute, Baylor Scott and White Health, Dallas, Texas, USA
3
Baylor Annette C and Harold C Simmons Transplant Institute, Baylor Scott and White Health, Dallas, Texas, USA
4
College of Medicine, Texas A&M Health Science Center, Texas A&M University, Dallas, Texas, USA
5
Division of Infectious Disease, Baylor University Medical Center, Dallas, Texas, USA
6
Texas Centers for Infectious Disease Associates, Dallas, Texas, USA
Robert L Gottlieb
1
Baylor Scott & White Research Institute, Baylor Scott and White Health, Dallas, Texas, USA
2
Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, Texas, USA
3
Baylor Annette C and Harold C Simmons Transplant Institute, Baylor Scott and White Health, Dallas, Texas, USA
4
College of Medicine, Texas A&M Health Science Center, Texas A&M University, Dallas, Texas, USA
7
Division of Precision Medicine, Baylor University Medical Center, Dallas, Texas, USA
8
Department of Internal Medicine, TCU and UNTHSC School of Medicine, Fort Worth, Texas, USA

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ALLY in fighting COVID-19: magnitude of albumin decline and lymphopenia (ALLY) predict progression to critical disease
Johanna S van Zyl, Amit Alam, Joost Felius, Ronnie M Youssef, Dipesh Bhakta, Christina Jack, Aayla K Jamil, Shelley A Hall, Göran B Klintmalm, Cedric W Spak, Robert L Gottlieb
Journal of Investigative Medicine Mar 2021, 69 (3) 710-718; DOI: 10.1136/jim-2020-001525

ALLY in fighting COVID-19: magnitude of albumin decline and lymphopenia (ALLY) predict progression to critical disease
Johanna S van Zyl, Amit Alam, Joost Felius, Ronnie M Youssef, Dipesh Bhakta, Christina Jack, Aayla K Jamil, Shelley A Hall, Göran B Klintmalm, Cedric W Spak, Robert L Gottlieb
Journal of Investigative Medicine Mar 2021, 69 (3) 710-718; DOI: 10.1136/jim-2020-001525
ALLY in fighting COVID-19: magnitude of albumin decline and lymphopenia (ALLY) predict progression to critical disease
Johanna S van Zyl, Amit Alam, Joost Felius, Ronnie M Youssef, Dipesh Bhakta, Christina Jack, Aayla K Jamil, Shelley A Hall, Göran B Klintmalm, Cedric W Spak, Robert L Gottlieb
Journal of Investigative Medicine Mar 2021, 69 (3) 710-718; DOI: 10.1136/jim-2020-001525