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Prevalence and determinants of severity of uremic pruritus in hemodialysis patients: a multicentric study

Amany M Abdallah, Samaa M Elsheikh, Rasha A ElBarbary
DOI: 10.1136/jim-2022-002360 Published 3 October 2022
Amany M Abdallah
1Internal Medicine Department, Al-Azhar University, Cairo, Egypt
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Samaa M Elsheikh
2Dermatology Department, Alexandria University, Alexandria, Egypt
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Rasha A ElBarbary
3Dermatology and Venereology Department, Al-Azhar University, Cairo, Egypt
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Abstract

Uremic pruritus (UP) is a common and distressing symptom in patients with advanced or end-stage renal disease under hemodialysis (HD). The present multicentric study aimed to identify prevalence and determinants of severity of UP among Egyptian patients. Performed investigations included serum urea, creatinine, calcium, phosphorus, parathormone, ferritin and liver enzymes. Pruritus was evaluated using the visual analog scale. The study included 295 patients on maintenance HD. They comprised 151 patients (51.2%) with UP. Independent predictors of UP included associated hypertension (OR: 0.48, 95% CI 0.28 to 0.83, p=0.008), higher calcium levels (OR: 1.29, 95% CI 1.02 to 1.62, p=0.032), higher phosphorus levels (OR: 1.18, 95% CI 1.02 to 1.37, p=0.03) and higher high-sensitivity C-reactive protein (hsCRP) levels (OR: 1.0, 95% CI 1.0 to 1.01, p=0.049). Independent predictors of significant UP included longer HD duration (OR: 1.23, 95% CI 1.1 to 1.38, p<0.001), lack of vitamin D supplementation (OR: 3.71, 95% CI 1.03 to 13.4, p=0.045), lower albumin levels (OR: 0.32, 95% CI 0.14 to 0.74, p=0.008) and higher hsCRP levels (OR (CRP): 1.02 (1.0–1.03), p=0.011). In conclusion, UP is fairly common among Egyptian HD patients. Independent predictors of UP severity include longer HD duration, lack of vitamin D supplementation, lower albumin levels and higher hsCRP levels.

Footnotes

  • Contributors AMA and RAE contributed to this work through study planning, conception and design. SME contributed to this work through data acquisition and analysis and manuscript drafting. AMA and RAE revised and approved the manuscript. AMA is responsible for the overall content as guarantor.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

Data availability statement

Data are available upon reasonable request.

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Journal of Investigative Medicine: 70 (8)
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Prevalence and determinants of severity of uremic pruritus in hemodialysis patients: a multicentric study
Amany M Abdallah, Samaa M Elsheikh, Rasha A ElBarbary
Journal of Investigative Medicine Oct 2022, jim-2022-002360; DOI: 10.1136/jim-2022-002360

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Prevalence and determinants of severity of uremic pruritus in hemodialysis patients: a multicentric study
Amany M Abdallah, Samaa M Elsheikh, Rasha A ElBarbary
Journal of Investigative Medicine Oct 2022, jim-2022-002360; DOI: 10.1136/jim-2022-002360
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Prevalence and determinants of severity of uremic pruritus in hemodialysis patients: a multicentric study
Amany M Abdallah, Samaa M Elsheikh, Rasha A ElBarbary
Journal of Investigative Medicine Oct 2022, jim-2022-002360; DOI: 10.1136/jim-2022-002360
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